Cisplatin induced apoptosis

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August undefined, 2024

WebTo study the mechanism of apoptosis induced by cisplatin in vitro in HeLa cells cervical cancer cell line. The inhibitory effect of cisplatin on HeLa cell growth was analyzed by … WebFeb 10, 2024 · Apoptosis and cell cycle analysis also showed that BCAAs or Leu treatment significantly increased cisplatin-induced apoptosis (Figure S3A) and reduced the proportion of cells in G2/M phase after ...

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WebJul 1, 1999 · The results thus far suggest that CP70 and C30 cells initiate apoptosis via a caspase-3-dependent pathway. However, even in the absence of caspase-3 activation, A2780 cells do exhibit some morphological characteristics of cisplatin-induced apoptosis, including a subset of the biochemical features of PCD. WebRenal tubular epithelial cell apoptosis is the main mechanism of cisplatin-induced acute kidney injury. The role of microRNAs (miRNAs) in the apoptosis of renal tubular epithelial cells has... order exodus effect oil

Cisplatin induced Mitochondrial DNA Damage In Dorsal Root …

WebApr 11, 2024 · Illustration of MAPK pathway and the role of cisplatin in promoting apoptosis or cell survival. Cisplatin-induced ERK activation phosphorylates p53 which in turn upregulates expression of p21, 45kd-growth arrest and DNA damage (GADD45), and mouse double minute 2 homolog (Mdm2) thereby promoting cell cycle arrest and … WebApr 14, 2024 · Since HK-2-cells-generated-Abs, both by cisplatin or upon UV light exposure, can induce apoptosis in HK-2 cells, the purpose of this work was to study their metabolome and therein find the molecular features which help us to unravel the mechanisms of that phenomenon. WebVarious recent studies have investigated (GLP-1R) role in cardiovascular diseases due to antiapoptotic and antioxidant effects. The current study aimed to investigate the curative … order execution in salesforce

Cisplatin-induced renal cell apoptosis: caspase 3-dependent and ...

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WebMoreover, DSF sensitized ovarian cancer cells to cisplatin treatment and enhanced cisplatin-induced apoptosis, both in SDC and MDC. In the present studies, we have used a quantitative method to determine synergism or antagonism of DSF in chemotherapy drug treatment. Three pairs of two-drug combinations and a three-drug combination were … WebFeb 13, 2024 · Mechanistic analyses indicated that cisplatin-induced caspase-3-dependent apoptosis was elevated in the presence of scutellarin through activating extracellular signal-regulated kinases (ERK)-mediated p53 pathway. Furthermore, scutellarin also promoted cisplatin-induced cytotoxic autophagy, downregulated expression of p-AKT and c-met. order execution unityWebMechanisms of Cisplatin-Induced Apoptosis and of Cisplatin Sensitivity: Potential of BIN1 to Act as a Potent Predictor of Cisplatin Sensitivity in Gastric Cancer Treatment Cisplatin is … irctc share prediction

"WebCisplatin-induced early-onset ototoxicity is linked to hearing loss. The mechanism by which cisplatin causes ototoxicity remains unclear. The purpose of this study was to identify … " - Cisplatin induced apoptosis

Cisplatin induced apoptosis

Direct impact of cisplatin on mitochondria induces ROS ... - Nature

WebSep 1, 2024 · By contrast, cisplatin-induced apoptosis and necroptosis were inhibited by treatment with Fer-1. Moreover, deferoxamine, an iron chelator, also inhibited CIN, with a decrease in the expression of COX-2 and 4-HNE. Conclusion. Ferroptosis is involved in the pathogenesis of CIN and might be used as a new preventive target for CIN. WebSep 15, 2024 · Cisplatin induces autophagy-associated apoptosis in human oral squamous cell carcinoma (OSCC) mediated in part through reactive oxygen species Toxicol Appl Pharmacol. 2024 Jul 15;115646. doi: 10.1016/j.taap.2024.115646. Online ahead …

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WebDec 12, 2024 · Cisplatin-induced AKI is characterised by increased apoptosis of renal tubular epithelial cells, and the results of the present study demonstrated that PSTPIP2 … WebOn the contrary, coadministration of 4-PBA reduces the expression of GRP78 and CHOP and enhances apoptosis in cisplatin-treated osteosarcoma cell lines, indicating that cisplatin-induced ER stress protects cell from apoptosis in these cell lines .

WebOct 5, 2014 · Cisplatin-Induced Cell Apoptosis Apoptosis is a controlled type of cell death which is energy-dependent leading to cell shrinkage, chromatin condensation, …

WebMay 1, 2001 · Cisplatin is one of the platinum-based drugs which act by crosslinking with DNA and thus interfere with cell division triggering apoptosis (Pruefer et al., 2008). In fact, Cisplatin causes cell ... WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different …

WebApr 1, 2016 · By using two pairs of genetically matched cisplatin-sensitive and cisplatin-resistant ovarian cancer cell lines, we tested the hypothesis that downregulating hypoxia-inducible factor-1 (HIF-1), which regulates metabolic enzymes involved in glycolysis, is a promising strategy for overcoming cisplatin resistance of human ovarian cancer cells.

WebCisplatin is the most important and efficacious chemotherapeutic agent for the treatment of advanced gastric cancer. Cisplatin forms inter- and intrastrand crosslinked DNA adducts … irctc share price googleWeb2-ME promoted the growth inhibitory and apoptosis-inducing effects of platinum-based agents in SKOV3 ovarian cancer cells and promoted the mRNA and protein expression of Bax, thereby, increasing the Bax/Bcl-2 expression ratio and activating the mitochondrial apoptosis pathway. 8 PDF irctc share price google financeWebNov 3, 2024 · Apoptosis is known as one of the major mechanisms of cisplatin-induced cell death in renal tubular which had been further confirmed in some studies [ 5, 6 ]. Some research data have also demonstrated that autophagy induction is an immediate response of renal tubular epithelial cell exposure to cisplatin [ 7, 8 ]. irctc share price in october 2021WebThe chemotherapeutic drug cisplatin elicits cytotoxicity causing renal tubular cell death, but its executing mechanisms of action are versatile and elusive. Here, we show that cisplatin induces renal tubular cell apoptosis and ferroptosis by … order exotic fruitsWebAim: To investigate the synergetic effect and the mechanism of antitumor action of the antibiotic lidamycin in combination with cisplatin in vitro. Methods: Cytotoxicity of the drugs was measured by clonogenic assay. Chromatin condensation was observed by co-staining with fluorescent dyes, Hoechst 33342 and propidium iodide. Apoptotic sub-G1 was … order exotic meats onlineWebThe role of intra- and extracellular pH in apoptosis induction was investigated. Activation of caspase-3 and DNA ladder formation were used to monitor the apoptotic response. … order exercises hackerrank solutionWebDec 8, 2024 · We observed that combined treatment with mdivi-1 and cisplatin induced downregulation of c-FLIP expression (Figure 2 C). c-FLIP is a major anti-apoptotic protein and is involved in death receptor-mediated apoptosis and chemotherapeutic drug resistance in cancer cells . To investigate the role of c-FLIP downregulation in combined … irctc share price today news youtube