WebComplex I is the first enzyme of the mitochondrial electron transport chain. There are three energy-transducing enzymes in the electron transport chain - NADH:ubiquinone oxidoreductase (complex I), Coenzyme Q – cytochrome c reductase (complex III), and cytochrome c oxidase (complex IV). [1] In Bacillus megaterium and Bacillus subtilis, POR is a C-terminal domain of CYP102, a single-polypeptide self-sufficient soluble P450 system (P450 is an N-terminal domain). The general scheme of electron flow in the POR/P450 system is: The definitive evidence for the requirement of POR in cytochrome-P450-mediated reactions came from the work of Lu, Junk and Coon, who dissected the P450-containing mixed function oxidas…
Mitochondrial ubiquinol-cytochrome c reductase complex …
WebMar 29, 2024 · Gene ID: 27089, updated on 29-Mar-2024. Summary. This gene encodes a ubiquinone-binding protein of low molecular mass. This protein is a small core-associated protein and a subunit of ubiquinol-cytochrome c reductase complex III, which is part of the mitochondrial respiratory chain. WebComplex III (ubiquinol-cytochrome c oxidoreductase) is the third of five OXPHOS complexes. Complex III assembly relies on the coordinated expression of the mitochondrial and nuclear genomes, with 10 subunits encoded by nuclear DNA and one by mitochondrial DNA (mtDNA). Complex III deficiency is a debilitating and often fatal disorder that can ... control key functions
A cytochrome cd1-type nitrite reductase mediates the …
WebRespiratory nitrite reductase (NIR) has been purified from the soluble extract of denitrifying cells of Alcaligenes eutrophus strain H16 to apparent electrophoretic homogeneity. The enzyme was induced under anoxic conditions in the presence of nitrite. Purified NIR showed typical features of a cytochrome cd1-type nitrite reductase. WebSuccinate dehydrogenase (SDH) or succinate-coenzyme Q reductase or mitochondrial complex II, is a multimeric enzyme bound to the inner mitochondrial membrane. It transfers electrons directly to the ubiquinone pool in Krebs cycle and the respiratory chain (Table 1 ). SDH consists of hydrophilic subunits, a flavoprotein (SDHA), and an iron-sulfur ... WebComplex I (reduced nicotinamide-adenine dinucleotide phosphate-coenzyme Q reductase) is the largest complex of the respiratory chain, containing about 46 polypeptides. Seven of the polypeptides are encoded by mtDNA, and mutations affecting exclusively the mtDNA genes will be considered separately under the heading of “mitochondrial genetics.” falling church