Lamp2b信号肽

Author: mcab

August undefined, 2024

TīmeklisLAMP2B is the predominant isoform expressed in cardiomyocytes. This study evaluates the efficacy of human LAMP2B gene transfer using a recombinant adeno-associated virus 9 carrying human LAMP2B (AAV9.LAMP2B) in a Lamp2 knockout (KO) mouse, a … Tīmeklis2016. gada 27. sept. · 1. A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy 思路：改造Exosome表面蛋白使其特异性靶向癌细胞，使其内部装载药物靶向释放，特异性杀灭癌细胞。这篇文章将iRGD 肽段：CRGDKGPDC (可与肿瘤细胞特异性高表达的αv integrin特异性结合)和 …

LAMP2B抗体- Lysosome Marker Abcam中文官网

Tīmeklis2024. gada 23. maijs · The expression of CTP-Lamp2b peptide on exosomes was stabilized by attaching glycosylation sequences. Exosomes expressing only Lamp2b on exosomal membranes (CTL-Exo) were generated as a control. The in vitro and in vivo uptake of CTL-Exo and CTP-Exo was evaluated in cell lines and mice. Both … TīmeklisReceive email alerts when new plasmids with this gene become available. Log in to subscribe to Addgene Alerts. Description lysosomal associated membrane protein 2. Also known as CD107b, DND, LAMP-2, LAMPB, LGP-96, LGP110. Species Homo sapiens. Entrez ID 3920. MGC ID BC002965. my body is a temple lds

SciAdv丨LAMP2A介导了蛋白质向外泌体的分选和包装 - 外泌体资 …

Tīmeklis定制系统分为蛋白质递送系统与RNA递送系统，蛋白质包装系统内含有3个质粒:第一个载有目的蛋白质包装装置(CD63+目的蛋白)；第二个载有特殊靶向运送功能的模块(例 … Tīmeklis2015. gada 27. marts · Indeed, peptides fused to the N terminus of exosome-associated transmembrane protein Lamp2b were cleaved in samples derived from both cells and exosomes. To suppress peptide loss, we engineered targeting peptide-Lamp2b fusion proteins to include a glycosylation motif at various positions. Introduction of this … Tīmeklis2024. gada 15. dec. · Abstract. Huntington’s disease is an autosomal-dominant neurodegenerative disease caused by CAG expansion in exon 1 of the huntingtin (HTT) gene.Since mutant huntingtin (mHTT) protein is the root cause of Huntington’s disease, oligonucleotide-based therapeutic approaches using small interfering RNAs … how to pay with paypal on ioffer

LAMP-2B regulates human cardiomyocyte function by mediating …

TīmeklisLAMP-2 Antibody (H4B4) is an IgG 1 κ mouse monoclonal LAMP-2 antibody (also designated LAMP2 antibody, LAMPB antibody or lysosomal associated membrane … Tīmeklis2024. gada 25. marts · In addition, images also showed that LAMP2B colocalization with LAMP2A is lower than expected (73.88 ± 13.09%), indicating that both LAMP2 isoforms are often segregated into different vesicles (fig. S6C). Overall, our evidence indicates that LAMP2A, but not LAMP2B, participates in the loading of proteins containing … how to pay with paysafecard on epic gamesTīmeklis2024. gada 15. nov. · 细胞外小囊泡（ sEVs RVG ）的脑部神经特异性靶向是通过将 s EVs膜蛋白lamp2b 和神经靶向性的狂犬病毒糖蛋白衍生肽（RVG）融合递呈在 … my body is a temple meme

"Tīmeklis2024. gada 8. janv. · Remarkably, LAMP-2B functions independently of syntaxin 17 (STX17), a protein that is essential for autophagosome-lysosome fusion in non-CMs. … " - Lamp2b信号肽

Lamp2b信号肽

TīmeklisThe fusion protein HuR-Lamp2b and Lamp2b-HuR were detected in the exosomes derived from HuRLamp2b and Lamp2b-HuR-transfected cells ( Supplementary Figure 1), suggesting that both Lamp2b fusion ... TīmeklisPlasmid pcDNA GNSTM-3-RVG-10-Lamp2b-HA from Dr. Joshua Leonard's lab contains the insert Lamp2b and is published in J Biol Chem. 2015 Mar 27;290(13):8166-72. doi: 10.1074/jbc.M114.621383. Epub 2015 Feb 5. This plasmid is …

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Tīmeklis2024. gada 21. marts · LAMP2 (Lysosomal Associated Membrane Protein 2) is a Protein Coding gene. Diseases associated with LAMP2 include Danon Disease and Left Ventricular Noncompaction.Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System.Gene Ontology (GO) annotations … Tīmeklis2024. gada 18. marts · LAMP2B is the predominant isoform expressed in cardiomyocytes. This study evaluates the efficacy of human LAMP2B gene transfer …

Tīmeklis信号肽（signal peptide）也叫信号序列（signal sequence），是膜蛋白、分泌蛋白和溶酶体蛋白的定位标签，通常位于蛋白质的氨基端，由13-26个残基组成。信号肽没有 … Tīmeklis2024. gada 1. febr. · The pEGFP-C1-RVG-Lamp2b expressing vector was kindly provided by Prof. Matthew J A Wood’ lab from University of Oxford [70]. DNA sequence encoding the glycosylation sequon (GNSTM), E7 Peptide [55] and a glycine-serine spacer were synthesized and subcloned to replace the RVG fragment by XhoI/BspeI …

Tīmeklis2024. gada 24. dec. · LAMP-2B is the predominant LAMP-2 isoform expressed in human CMs. ( A) Expression of the three LAMP-2 isoforms in different types of cells was examined by RNA-seq or qPCR. RNAs from three human hearts were used for qPCR. FPKM, fragments per kilobase of exon per million reads. ( B) Immunoblotting … TīmeklisAll lanes : Anti-LAMP2B antibody - Lysosome Marker (ab18529) at 1 µg/ml Lane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 2 : HEK293 (Human) Whole Cell Lysate Lysates/proteins at 20 µg per lane. Secondary All lanes : Goat Anti-Rabbit IgG H&L (HRP) preadsorbed at 1/50000 dilution Developed using …

Tīmeklis购买Abcam重组人LAMP2B蛋白(ab151915)，经SDS-PAGE,HPLC验证。蛋白片段。提供28,000多种信号蛋白、细胞因子、趋化因子、生长因子等产品。

http://www.biofeng.com/adjy/zhili/pcDNA%20GNSTM-3-RVG-10-Lamp2b-HA.html my body is aching meaningLysosome-associated membrane protein 2 (LAMP2), also known as CD107b (Cluster of Differentiation 107b) and Mac-3, is a human gene. Its protein, LAMP2, is one of the lysosome-associated membrane glycoproteins. The protein encoded by this gene is a member of a family of membrane glycoproteins. This … Skatīt vairāk The gene for LAMP2 has 9 coding exons and 2 alternate last exons, 9a and 9b. When the last exon is spliced with the alternative exon, it is a variant called LAMP2b, which varies in the last 11 amino acids of its C … Skatīt vairāk Lysosomes are cell organelles found in most animal cells. Their main functions center around breaking down materials and debris in the cell. Some of this is done via acid hydrolases that degrade foreign materials and have specialized autolytic functions. These … Skatīt vairāk • CA77.1 • QX39 Skatīt vairāk • Chang MH, Karageorgos LE, Meikle PJ (2003). "CD107a (LAMP-1) and CD107b (LAMP-2)". Journal of Biological Regulators and Homeostatic Agents. 16 (2): 147–51. Skatīt vairāk LAMP2 has been specifically implicated in tumor cell metastasis. Both LAMP1 and LAMP2 have been found expressed on the surface of cancerous tumors, specifically in cells of highly metastatic cancer such as colon cancer and melanoma. They are rarely found on … Skatīt vairāk • Cluster of differentiation Skatīt vairāk • LAMP2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • PDBe-KB provides an overview of all the structure information … Skatīt vairāk how to pay with paypal on etsyTīmeklis2024. gada 5. jūl. · 信号肽捕获系统 (signal sequence trap, SST) 就是依据分泌性蛋白质的这一特性进行基因克隆的功能性基因克隆系统 , 由 Tashiro K 等于 1993 年建立, 该方法可以快速、大量地克隆真核细胞编码分泌性蛋白的基因序列, 目前用该系统已经获得了大量编码分泌性蛋白的基因 [4]。 SST 法包括两个基本步骤: ( 1) 构建并转染和报告基 … my body is a temple of the holy spiritTīmeklis载体简介载体序列 LOCUS pcDNA GNSTM-3-RVG-10-Lamp2b-HA 6988 bp ds-DNA circular SYN 06-AUG-2024 DEFINITION Encodes (N to C): GNSTM glycosylation motif, 3 residue spacer, RVG peptide, 10 residue spacer, Lamp2b (exosomal transmembrane protein), 3 residue spacer, HA tag.. ACCESSION . VERSION . my body is aching so badTīmeklis2015. gada 29. marts · 表达一个困难的基因就像砸碎一个硬坚果，有时候你需要借助外力。. 为了获得一个有用的蛋白，很重要的一点就是保证蛋白质正确折叠。. 细胞质（cytoplasm）的环境是还原性 (reducing)的，这不利于二硫键的正确形成，因此会影响蛋白质的折叠。. 为了辅助蛋白质 ... how to pay with paypal on fiverrTīmeklis2024. gada 24. nov. · Lamp2b-HuR融合蛋白功能化的外泌体能够将被RNA结合基序识别的RNA靶标驱动至溶酶体以在受体细胞中降解。该系统在富含溶酶体的巨噬细胞中 … my body is a wonderland songTīmeklis利用携带软骨细胞的亲合肽（CAP）融合表达展示于外泌体膜蛋白（lamp2b）上表面作为靶向的基因工程化外泌体可实现靶向软骨细胞（图1）。与无靶向的天然外泌体相 … my body is a temple verse