The intestinal heme transporter revealed

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August undefined, 2024

WebOct 1, 2005 · The Intestinal Heme Transporter Revealed Authors: Tracey A Rouault U.S. Department of Health and Human Services Request full-text Abstract The iron-containing … WebSep 1, 2005 · This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our …

SANTA CRUZ BIOTECHNOLOGY, INC. HCP1 (B-4): sc-393460

WebJun 2, 2024 · Combining genetic, biochemical, and immunofluorescent methods, we revealed that CG4562 works as a heme exporter in the intestine and plays a critical role in exporting heme to the body (presumably hemolymph), analogous to MRP5 in mammals. Furthermore, we found that the homolog of CG4562 in yellow fever mosquito also … WebThe Intestinal Heme Transporter Revealed The iron-containing porphyrin heme provides a rich source of dietary iron for mammals. The fact that ani-mals can derive iron from heme … fennel and celery root casserole

Iron uptake mediated by the plant-derived chelator nicotianamine …

WebSep 23, 2024 · Moreover, an intestinal heme transporter called HCP-1 was identified 4, which was also discovered as an intestinal folate transporter in a subsequent study 43. WebSep 9, 2005 · This transporter, which they call heme carrier protein 1 (HCP1), transports iron bound to heme from the gut lumen into duodenal epithelial cells; the iron is then released … WebThis study aimed to understand the mechanism of NA-mediated intestinal iron uptake, by identifying the NA-Fe (II) complex transporter in the intestine. The findings demonstrated … dekalb county sheriff\u0027s office alabama

The Intestinal Heme Transporter Revealed - National Institutes of …

Ze brafish as a model system to delineate the role of heme and …

WebAug 15, 2014 · A candidate intestinal heme transporter, heme carrier protein 1 (HCP1), was proposed , ... Many of the complexities of HEPC regulation have been revealed, and this has shown that HEPC is an integral part of each of the signaling pathways formerly known as the “stores,” “erythropoetic” and “inflammatory” regulators of iron ... WebDec 31, 2015 · This transporter, which they call heme carrier protein 1 (HCP1), transports ironIt had been established long ago that the duodenal mu- bound to heme from the gut … fennel and celery root soupWebSep 10, 2008 · Studies showed that haem enters the small-intestinal absorptive cell as an intact Fe-porphyrin, and may be facilitated by a vesicular transport system (22), presumably binding first to the brush-border membrane of enterocytes, then undergoing internalisation into the cytoplasm, finally appearing within enclosed vesicles (23) and being broken down … fennel and celery recipes

"WebSep 9, 2005 · Our results identify HCP1 as an intestinal heme transporter capable of mediating energy-dependent, transmembrane uptake of the intact metaloporphyrin ring. … " - The intestinal heme transporter revealed

The intestinal heme transporter revealed

Haem and folate transport by proton-coupled folate transporter…

WebSep 9, 2005 · Our results identify HCP1 as an intestinal heme transporter capable of mediating energy-dependent, transmembrane uptake of the intact metaloporphyrin ring. … WebDownload The Intestinal Heme Transporter Revealed Cell 650 Figure 1. The Duodenal Mucosa of the Gut Is the Main Site of Iron Absorption in Mammals (Left) Heme carrier …

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WebHCP1 (heme carrier protein 1), also known as proton-coupled folate trans-porter (PCFT), is a multi-pass transmembrane protein that is expressed in the ... Rouault, T.A. 2005. The intestinal heme transporter revealed. Cell 122: 649-651. 2. Shayeghi, M., et al. 2005. Identification of an intestinal heme transporter. Cell 122: 789-801. CHROMOSOMAL ... WebSep 9, 2005 · The Intestinal Heme Transporter Revealed The iron-containing porphyrin heme provides a rich source of dietary iron for mammals. The fact that animals can derive …

WebWorms respond to heme availability by regulating heme-responsive genes such as hrg-1, an intestinal heme transporter that is up-regulated by >60-fold during heme depletion. To identify the mechanism for the heme-dependent regulation of … WebNEW INSIGHTS INTO INTESTINAL HEME AND NON-HEME IRON ABSORPTION: REGULATION BY DIETARY FACTORS A Dissertation in Nutrition by ... Previous studies have revealed the inhibiting effect of polyphenols from black tea on ... Temperature-dependent uptake and transport of heme-55Fe in Caco-2 cells ...

WebMutations in DMT1 and Ireg1 have revealed that these molecules are major mediators of iron transport across the brush border and basolateral membranes of the enterocyte, respectively. ... ArticleTitle Characterization of a human plasma membrane heme transporter in intestinal and hepatocyte cell lines Am J␣Physiol 280 G1172–G1177 ... WebJun 16, 2024 · The intestinal heme transporter revealed. Rouault TA. Cell, 122(5):649-651, 01 Sep 2005 Cited by: 17 articles PMID: 16143096. Review. Heme Uptake and Utilization by Gram-Negative Bacterial Pathogens. Richard KL, Kelley BR, Johnson JG. Front Cell Infect ...

WebJun 2, 2024 · Combining genetic, biochemical, and immunofluorescent methods, we revealed that CG4562 works as a heme exporter in the intestine and plays a critical role in …

WebApr 11, 2012 · Heme carrier protein 1 (HCP1) was originally identified as mediating heme-Fe transport although it later emerged that it was a folate transporter. We asked what happened to heme-Fe and... dekalb county social servicesWebSep 9, 2005 · The identification of HCP1 is an important accomplishment that supplies a key missing piece in our understanding of iron uptake and mammalian nutrition. HCP1 is … dekalb county snap programWebJul 29, 2010 · This work identifies a novel list of 288 heme-responsive genes (hrgs) in C. elegans and a number of related genes in humans and medically relevant parasites. … dekalb county solar projectsWebSep 9, 2005 · Here we show a membrane protein named HCP 1 (heme carrier protein 1), with homology to bacterial metal-tetracycline transporters, mediates heme uptake by cells in a … dekalb county special election 2021WebAug 10, 2015 · In the last few years, important advances have been made, including the discovery of three types heme transporters in eukaryotic cells: the feline leukemia virus receptor (FLVCR) [10, 11], intestinal heme transporter and heme regulated genes 1–4 (HRG) . In contrast, the participation of ABC transporters in heme movement across membranes … dekalb county sheriff\u0027s department alabamaWebSep 1, 2005 · Search worldwide, life-sciences literature Search. Advanced Search Coronavirus articles and preprints Search examples: "breast cancer" "breast cancer" dekalb county special victims unitWebFeb 26, 2024 · This experiment was conducted to investigate the transport characteristics of iron from ferrous bisglycinate (Fe-Gly) in intestinal cells. The divalent metal transporter 1 (DMT1)-knockout Caco-2 cell line was developed by Crispr-Cas9, and then the cells were treated with ferrous sulfate (FeSO4) or Fe-Gly to observe the labile iron pool and … dekalb county solid waste